Is Hypoxic/Altitude Training an Important Topic in the Field of Hypoxia?

Abstract Hypoxia is an essential topic in medical or biological sciences. The main aims of the present study were to examine most important articles (i.e., top 100 cited) on hypoxia. We how Nobel-prize awarded hypoxia inducible factor (HIF)-pathway discovery early 1990s has changed thematic composition this body literature, with a special emphasis studies linking and cancer. searched Pubmed for terms #Hypox, #Altitude, #Mountain title that have been published biomedical journals ranked their number citations Web Science. A second search was performed all related Strikingly, only 12 top-100 most-cited 3 cancer before 1995. Moreover, 5 from prior 1995 reached 1000 citations, while 27 later cited more than times, them HIF-1 pathway. Eighty percent HIF pathway, there no application either therapeutic use hypoxic conditioning patients) performance enhancement altitude training athletes). In conclusion, early-1990s pathway its molecular regulation shifted focus research towards mechanisms consequences tissue hypoxia, notably importance focusing clinical applications systemic relatively lower.